Formulation and Evaluation of Floating Microspheres of Atenolol

Abstract

The objective of the present investigation was to prepare floating microsphere of atenolol to improve the bioavailability by increasing residence time in stomach. The microspheres of atenolol were prepared ed formulations were subjected to evaluation as FTIR, particle size, size distribution, % yield, drug content, buoyancy study, entrapment efficiency and in vitro dissolution. The FTIR spectra revealed that, there was no interaction between polymer and atenolol. The polymers used were compatible with atenolol. As the drug tby solvent evaporation technique using ethyl cellulose as polymer at different concentration. The preparo polymer ratio was increased, mean particle size of atenolol floating microspheres was also increased. Atenolol floating microspheres with normal frequency distribution were obtained.

Entrapment efficiency increased with increase in polymer concentration. From the results it can be inferred that there was the proper distribution of atenolol in the microspheres. On the basis of release data and graphical analysis formulation F-3 shows good controlled release profile with maximum entrapment efficiency because of high polymer concentration.