In Vitro Evaluation of Anthelmintic Activity of Glycerine on Indian Earthworms

Abstract

One of the well-known pharmaceutical ingredients- Glycerine showed significant anthelmintic results after lot many experimental trials. Thus Glycerine is acting as a potent anthelmintic agent and it does so by exerting its osmotic dehydration property. Experimental trials were carried out using Indian earthworms (Pheretima Posthuma). The various concentrations were tested for Anthelmintic activity & Albendazole is used as a standard for comparison.

This is the first attempt to reveal the anthelmintic activity of glycerine which is not yet reported anywhere. The effect of Glycerine against parasite was observed in very shorter time. It shows paralysis time 101 seconds and death time 104 seconds which is much superior to that of Albendazole (14.53 minutes and 23.46 minutes). By in vitro evaluation it is proved that Glycerine potentiates paralysis in earthworm & ultimately it results in death of worms.