Non Alcoholic Fatty Liver Disease: Does It Really Matters?

Abstract

In past few decades the incidence and prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) has been increasing in western and Asian countries. Several lines of evidence have indicated a pathogenic role of insulin resistance, and a strong association with type 2 diabetes (T2MD) and metabolic syndrome. Currently Vitamin E has been recommended as firdst line treatment for Non-alcoholic Fatty liver disease in patients who are not alcoholics. India has the largest number of people with diabetes. Moreover, Asian Indians are more prone to insulin resistance and have increased waist circumference and body fat (particularly visceral fat), features that are described as the Asian Indian phenotype. However limited data is available on prevalence and incidence of NAFLD in India. In the present review we tried to explore the current pathophysiology and treatment options and how important is the disease condition.