Formulation and In Vitro evaluation of self-nano emulsifying drug delivery system (SNEDDS) containing an anti-HIV drug

Abstract

The aim of the research work was to formulate & characterize self-nano emulsifying drug delivery system (SNEDDS) containing an anti-HIV drug for non-invasive delivery. SNEDDS were isotropic mixture of oil, surfactant and cosurfactant. A fixed amount of anti-HIV drug (150mg) was present in each formulation. The solubility studies of the drug were carried out in various vehicles of oils, surfactants and cosurfactants. Pseudoternary phase diagrams were constructed for identifying required self-emulsification region. The optimized formulation containing the fixed amount of drug was assessed by drug content, spectroscopic clarity, emulsification time, phase separation, particle size, FT-IR and dissolution studies. Prepared formulations had good optical clarity, all formulations scare of phase separation and carried good emulsification time with almost 100% drug content. FT-IR analysis study indicates good compatibility of the drug with the excipients. Particle size of maximum formulations was less than 100 nm with better poly dispersivity index (PDI). Comparative dissolution study shows that much better drug release from SNEDDS than a branded tablet and pure drug molecule. These results concluded the potential of SNEDDS as an efficient way of enhancing the dissolution of the anti-HIV drug which may improve the oral absorption.