Protective Effect of Piper Betel Leaves Extract in the Treatment of Oral Submucous Fibrosis in Rats

Abstract

The aim is to study the Protective effect of aqueous extract of leaves of Piper Betel in the treatment of Oral Submucous fibrosis in rats. Rats were divided into three groups, group 1 and 2 five rats each and group 3 consisted of fifteen rats. Group 1 served as control and was not given any application. Group 2 rats were applied muco-adhesive paste of Gutkha and evaluated for the progress of OSMF for 3, 6 and 12 months respectively through biopsies. Group 3 rats were also applied muco-adhesive paste of Gutkha for 3, 6 and 12 months respectively, and on confirmation of OSMF induction through biopsies, muco-adhesive paste of aqueous extract of Piper Betel leaves was applied for 3, 6 and 12 months. Biopsies were taken on completion of the study. Treatment with aqueous extract of leaves of Piper Betel was found to restore the histological characteristics of normal mucosa in response to the duration of OSMF induction and treatment. Present study shows that aqueous extract of Piper Betel leaves holds pr