A Review on Anticancer drug delivery through Micro based Structure

Abstract

The development of chemotherapy using conventional anticancer drugs has been hindered due to some drawbacks related to their poor water solubility and poor pharmacokinetics, leading to severe adverse side effects and multidrug resistance in patients. Micro carriers were developed to palliate these problems by improving drug delivery, opening the era of micro medicine in oncology. However, despite attractive results being obtained in preclinical studies, many well-designed micro drugs fell short of expectations when tested in patients, evidencing the gap between micro particle design and their clinical translation. The aim of this review is to evaluate the extent of micro therapeutics used in oncology. The reasons that prevent micro drugs from expanding to clinic are discussed, and the efforts that must be taken to take full advantage of the great potential of micro medicine are highlighted.