Floating Microspheres Encapsulating Amoxicillin for Effective Treatment of Peptic Ulcer

Anurag Dubey; Anshul Tiwari; Ankur Singai; Sunil Kumar Jain; Mahak Jain

Anurag Dubey Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001
Anshul Tiwari Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001
Ankur Singai Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001
Sunil Kumar Jain Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001
Mahak Jain Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001

Abstract

Although oral route of drug administration is preferred route of administration, drug absorption from the gastrointestinal (GI) tract may be very less and highly variable in certain circumstances. Certain drugs are required longer residence in upper GI tract. The gastro-tentative drug delivery is the approach for the such drugs which require longer residence in stomach and for the drugs with shorter half-life. Floating microspheres of amoxycillin trihydrate were prepared solvent evaporation method using polymethyl methacrylate. The effect of drug concentration, stirring speed and process temperature were optimized in the study. The in vitro drug release studies performed in the simulated gastric fluid shows 89.6±2.6% cumulative drug release at the end of 12 hours with the optimized batch, following Higuchi diffusion drug release kinetics. The prepared floating microspheres of the amoxycillin trihydrate were found to have adequate stability profile at ambient conditions.