Development and Evaluation of Levosulpiride Loaded Floating Microspheres for Gastrointestinal Disorder

Anshul Tiwari; Ankur Singai; Anurag Dubey; Sunil Kumar Jain; Mahak Jain

Anshul Tiwari Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001
Ankur Singai Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001
Anurag Dubey Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001
Sunil Kumar Jain Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001
Mahak Jain Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001

Abstract

In the present study the floating microspheres of the levosulpiride were prepared. The sodium alginate, sodium carbonate and HPMC K15m were selected as formulation variables. The characterization of prepared formulations was carried out. The drug release study shows that the four different formulations prepared gives cumulative drug release 73.49 to 88.13% at the end of drug release study. The highest drug release was obtained in LS3 batch. In vitro drug release profile indicated that drug release was retarded due to the presence of higher concentration of polymer. The sodium alginate, sodium carbonate and HPMC K15m in the ratio 1:2:1 respectively shows desired drug release properties. The formulations were quite stable at the ambient temperature conditions but accelerated temperature could affect the release behavior of the floating microspheres.