Preparation and Evaluation of Glimepiride Floating Microsphere for Effective Management of Diabetic Mellitus

Ankur Singai; Anshul Tiwari; Anurag Dubey; Ashi Jain; Sunil Kumar Jain; Mahak Jain

Ankur Singai Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001
Anshul Tiwari Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001
Anurag Dubey Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001
Ashi Jain Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001
Sunil Kumar Jain Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001
Mahak Jain Adina Institute of Pharmaceutical Sciences, NH-86, Bhopal Road, Sagar (M.P.), India-470001

Abstract

Floating gastroretentive drug delivery system is the choice for delivery of the drugs with shorter half-life and drug mainly absorbed from the stomach or duodenum. The floating microspheres of the antidiabetic drug glimepiride were developed to address the lower half issues with the drug. The development of formulation four formulations done using a different concentration of ethyl cellulose and HPMC-k15m. Formulation F2 selected as optimized formulation on the basis of drug entrapment, percent yield, and in-vitro buoyancy test. The value of drug entrapment and percent yield were found to be 76.90% and 78.69% respectively. The prepared formulations were found stable during stability testing at ambient conditions.