Crystal Engineering an Approach for Solubility Enhancement of Poorly Water Soluble Drugs

Abstract

Major limitation for product development of multiple drugs is the poor aqueous solubility. Crystal engineering is the best mechanism to improve the solubility. Cocrystallzation is bicomponent system in which bond formation takes place between drug and coformer which improve the solubility and flow properties of poorly water soluble drugs. Cocrystallization does not interfere with chemical properties and biological activity of drug. Improvement of flow and compressibility is an additional advantage of implementing cocrystallization for solubility improvement.